TransDEvo People

  • Manuel Irimia, Group Leader

    I studied Biology and Genetics at the UCM (Madrid) and after two years in Denmark and New Zealand working on (alternative) splicing evolution, I did my PhD at the Universitat de Barcelona, where I worked on (regulatory) genomic changes underlying the origin of vertebrates. I then did a short postdoc at Stanford University (USA) and a longer one at University of Toronto (Canada) investigating the function, conservation and regulation of cell type specific alternative splicing, specially of microexons. Our lab is now interested in any of those topics, Evolutionary Medical Genomics, or anything that relates to transcriptomics, development and/or evolution.

    Random facts: I love diving and traveling far away, and I try (hard) to play violin.

  • Jonàs Juan-Mateu, Staff Scientist

    I am a molecular biologist from Mallorca interested in understanding the molecular basis of human diseases. I obtained my PhD at the University of Barcelona studying the genetic and molecular mechanisms underlying muscular dystrophies. After a postdoc at the Free University of Brussels, my research interests shifted to the study of pancreatic islet biology and glucose metabolism. My work is focused in understanding the role of transcriptional and post-transcriptional regulatory programs, in particular alternative splicing, in the differentiation and function of hormone-secreting islet cells and its impact on diabetes.

    Random facts: I love history, mountains and electronic music.

Postdoctoral Researchers

  • John Chamberlin 🇺🇸

    I am a bioinformatician with a background in microbiology, statistics, and toxicology, but am currently most interested in the interplay between RNA biology and genome evolution. I completed my PhD in 2024 at the University of Utah Department of Biomedical Informatics (Salt Lake City, USA), where I focused on technical aspects of single-cell RNA-seq analysis. In the Irimia Lab, I am using comparative approaches to study the evolution and regulation of transcriptional processing mechanisms.

    Random facts: I used to rent a house on Chamberlin Avenue (no relation).

  • Ludovica Ciampi 🇮🇹

    I graduated in Biotechnology at the University of Napoli (Italy). Following my Master's studies on the molecular mechanisms of retinal disorders, I moved to the CRG for my PhD, to study photoreceptors and sensory cells from a transcriptomic, alternative splicing perspective. Currently, as a Postdoc, I integrate experimental and computational approaches to identify new splicing mutations in retinal diseases. I am also exploring sensory cell signatures across species with single-cell methods.

    Random facts: biking and climbing enthusiast, aspiring guitarist. In my free time, you can easily find me on a mountain.

  • Jordi Fernández-Albert 🇪🇸

    I completed my PhD thesis at the CSIC Institute of Neuroscience of Alicante, where I studied the epigenetic and transcriptional regulation of memory formation. Afterwards, I moved to Stanford University (USA) for a first Postdoc, where I continued researching on Neurogenomics at the single-cell multi-omic level. Following my passion for memory and evolution, I joined the Irimia lab to try to answer a fundamental problem in biology: what are the genomic and regulatory bases that support the de novo origin of cell-types in metazoans, particularly vertebrates.

    Random facts: I love skiing.

  • Federica Mantica 🇮🇹

    I studied Molecular Biotechnology as an undergrad at the University of Torino (Italy), but my passion has always been for bioinformatic in general and evolutionary projects in particular. After some research experiences in Sweden and Germany, I started my PhD at the CRG. I recently defended my thesis, where I studied the evolution of tissue-specific transcriptomes across bilaterian animals, with a particular focus on tissue-specific gene expression and alternative splicing. I am currently staying as a Postdoc to close up the remaining projects.

    Random facts: I love sunny weather, weird animals and long trips.

  • Antonio Jesús Montero Hidalgo 🇪🇸

    I am a biochemist interested in how cells respond and adapt to their cellular/metabolic milieu. After graduating from the University of Cordoba (Spain), I completed my master’s studies and PhD in biomedicine focused on characterizing the deregulation of the RNA metabolism, particularly splicing, in prostate and bladder cancer. I then became part of Irimia's lab, where I am trying to unveil the pathophysiological role of tissue-specific microexons and their regulators, with a special focus on their implication in diabetes.

    Random facts: I am a Star Wars fan that is passionate about video/board games, but I really love having scientific discussions while holding a beer.

  • Vasilis Papadogiannis 🇬🇷

    I am a biologist fascinated by how evolution has sculpted vertebrate genomes to build our embryonic architecture. I have a BSc in Biology from the University of Athens, an MSc in Biotechnology from the University of Edinburgh and a DPhil (PhD) in Zoology from the University of Oxford, where I investigated early vertebrate developmental genetics. During my first postdoc in the Hellenic Center for Marine Research, I also worked on teleost comparative genomics. My current project focuses on Conserved Non-Coding Elements, ancient genomic regions regulating key developmental genes, aiming to map CNE-gene contacts and understand how they function and evolve.

    Random facts: My dream situation is food and games with friends on a remote mountain or beach. I love hiking, cooking and running weird D&D campaigns. I also play the bouzouki and have a black belt in aikido.

PhD Students

  • Israel Campo Bes 🇪🇸

    I studied Biology at the University of Valencia (Spain), where I fell in love with evolution. Subsequently, I pursued a Master's in Evolutionary Biology, where I worked on the genetic basis and evolution of color polymorphism in stick insects (CNRS, Montpellier) and on the evolution of toxin-antidote systems in nematodes (IMBA, Vienna). Currently, I am a PhD student at Irimia's lab where I am trying to understand the zygotic genome activation in animals from an evolutionary perspective.

    Random facts: I love music

  • Renata Cunha 🇵🇹

    I studied Medicinal Biotechnology at the School of Health in Porto, Portugal, where I'm from. Following my passion on virus I did a Master's in Tropical Heatlh in Lisbon where I studied Hepatitis and Sars-Cov-2. Later I worked as a technician in zebrafish retina development and tissue morphogenesis. Now as a PhD studient at Irimia's Lab my goal is to study the influence of pancreas microexons in pancreas development and, its conservation across species.

    Random facts: I'm a retired classic ballet and contemporary dancer that loves to watch soccer.

  • Manu Fernández Moreno 🇪🇸

    I studied a bachelor’s in Biology and a master’s in Molecular Genetics at the University of Seville (Spain). I am interested in the evolution of animals and how new elements are integrated into complex networks. I am doing my PhD supervised by Manuel Irimia and Ignacio Maeso (University of Barcelona), in which I’m studying the domestication of retroviral capsids for neural functions, focusing on the ARC genes, both in tetrapods and dipterans.

    Random facts: I love to spend time in Nature and observe animals.

  • Tahnee Mackensen 🇩🇪

    During my BSc (Hons) Neuroscience at The University of Edinburgh with a voluntary year abroad at McGill University I had the opportunity to be involved in various research projects ranging from brain organoids to fish behaviour. The latter inspired me to commence my PhD in the Irimia lab investigating zebrafish sleep/wake behaviour from a neuroscience perspective while learning more and more about transcriptomics and specifically alternative splicing.

    Random facts: Finally started sailing and am aspiring to become the lab pirate.

  • Liana Penteskoufi 🇬🇷

    After obtaining my bachelor’s degree in Biology at the University of Patras in Greece, I moved to Germany to pursue my master’s in Molecular Biosciences at Heidelberg University. During that time, I worked at DKFZ focusing on the epitranscriptome in cancer and naked mole-rats. For my PhD, I joined the lab of Manuel Irimia to understand how cell type specific genetic modules impact the developmental and evolutionary origin of pancreatic beta cells in vertebrates.

    Random facts: I love doing sports but even more I love watching reality shows about them. I also enjoy music and playing backgammon.

  • Matteo Zambon 🇮🇹

    I have a Bachelor's degree in Physics and a Master’s in Physics of Complex Systems from
    the University of Torino, my hometown. During my masters’ thesis, I focused on single cell gene expression profiles of embryonic organoids at Helmholtz Munich. After a research experience in Germany, I moved to the CRG for my PhD under the supervision of Manuel Irimia, Mafalda Dias and Jonathan Frazer with the perspective of leveraging transcriptomic and evolutionary information in the context of personalized medicine and medical genomics

    Random facts: I love music, I keep trying to play the guitar and the cajon, and I would probably say yes to any sport any friend would propose me.

Tech Team

  • Cristina Rodriguez Marin, Lab Manager 🇪🇸

    I studied Systems Biology Engineering at the UPC (Barcelona), where I started working with zebrafish. Thanks to this, I joined the lab as a zebrafish tech and learned a lot about molecular biology. Finding this passion led me to do a Master’s in Molecular Biotechnology, studying pancreas microexons in zebrafish. I am currently the Lab Manager and I finally found my place: being able to help everyone to do great science.

    Random facts: I find pottery the most relaxing activity after a crazy lab day; I'm a crazy cat lady, and flowers and plants always make me happy.

  • Marta Miret Cuesta, TC and Mouse Technician 🇪🇸

    I studied Biotechnology at the UAB (Spain). My main interests are transgenic technologies and I was incredibly lucky to work in PSS/GeMS - a transgenic facility - at the NIMR/The Francis Crick Institute under Sarah Hart-Johnson for 6 years. In 2017 I went back to my sunny roots and joined the lab. I really enjoy working in a research lab and applying my technical expertise to contribute to the different projects.

    Random facts: I once baked 6 cakes as a test for a friend's party (and the leftovers were very much enjoyed in the lab)

  • Luis Iñiguez Rabago, Senior Bioinformatician 🇲🇽

    I'm the proud Mexican bioinformatician in love with RNA of the Irimia lab. I did my PhD in Mexico at the UNAM working with alternative splicing and its evolution in legumes. I also spent some time in New York working at Weill Cornell Medicine, where I studied the expression of human endogenous retrovirus in cancer and upon viral infections. I'm involved in the data analysis and results visualizations of many projects of the lab.

    Random facts: I'm passionate about football and love to play as goalkeeper.

  • Miguel Torres-Martin

    Miguel Torres-Martin, Senior Bioinformatician 🇪🇸

    After completing my PhD in transcriptomics of nervous system tumors at La Paz University Hospital (Madrid), my professional path led me to the University of Michigan where I studied epigenetics of hematologic cancers. Afterwards, and within the same lab, I moved to the University of Miami, where I continued my research. My American experience concluded with another two years at the Mount Sinai Hospital in New York City studying transcriptomics and mutations in liver cancer. Then, I was transferred to IDIBAPS in Barcelona. In the most recent years, I have been working as a bioinformatician in the Genetics Department at the Germans Trias i Pujol Hospital.

    Random facts: I like mountain biking, cooking, and board games. But above all, I love playing Super Mario with my little kids.

Collaborators

  • Sophie Bonnal 🇫🇷

    I worked on IRES-mediated translation initiation during my PhD (at University Paul Sabatier, Toulouse, France) and delved into the intricacies of pre-mRNA splicing regulation by diverse RBPs during my time as Post-doc, and currently, as Staff Scientist in the Valcárcel lab at CRG. I can't pinpoint exactly when my passion for Life Sciences began, but an iodine test.

Master and Bachelor Students

  • Irene Zapata Bódalo 🇪🇸

Alumni

Niccolò Arecco - Postdoctoral Researcher (2019-2023)

Barbara Pernaute - Postdoctoral Researcher (2015-2022)

Thomas Spruce - Postdoctoral Researcher (2015-2022)

Amaya Lopez - Postdoctoral Researcher (2021-2021)

Yamile Marquez - Postdoctoral Researcher (2016-2020)

Mireya Plass - Postdoctoral Researcher (2019-2020)

Beth Kita - Postdoctoral Researcher (2016-2018)

Patryk Polinski - PhD Student + Postdoc (2017-2022)

Simon Bajew - PhD Student (2017-2021)

Laura Lopez-Blanch - PhD Student + Postdoc (2015-2022)

Reza Sodaei - PhD student (2015-2021)

Antonio Torres-Mendez - PhD Student + Postdoc (2015-2021)

Victoria Rodriguez-Vaello - PhD Student + Postdoc (2015-2021)

Chris Wyatt - PhD Student (2014-2019)

Javier Tapial - PhD Student (2014-2018)

Demián Burguera - PhD Student (2014-2017)

Didac Cañas - Fish technician (2022-2023)

Jon Permanyer - Lab Manager (2014-2023)

André Gohr - Bioinformatician (2015-2020)

Lucia Goyeneche - TC Technician (2016-2018)

Dominic Yap - Master Student (2024)

Daria Sels - Master Student (2024)

Elina Libman - Master Student (2023)

Daniel Soto - Master Student (2020-2021)

Mireia Codina - Master Student (2019-2020)

Quirze Rovira - Master Student (2015-2016)

Romeo Willinge Prins - Master Student (2015-2016)

Laia Sancho - Undergrad Student (2023-2024)

Maria Touceda-Suarez - Undergrad Student (2015-2016)

Orsolya Fölsz - Summer Intern (2021)

Pedro Bak-Gordon - Summer Intern (2020)

Rachel Levy - Summer Intern (2019)